The Leibniz-Institute of Freshwater Ecology and Inland Fisheries (IGB) is the largest research institute in Germany and it is an independent and interdisciplinary research centre dedicated to the creation, dissemination, and application of knowledge about freshwater ecosystems. Founded in 1992 on the recommendation of the German Science Council, it is a legal member of the Forschungsverbund Berlin e.V (FVB), which comprises eight research institutes that share a common administrative infrastructure and belong to the Leibniz Association. IGB has a matrix structure with disciplinary-oriented 6 Research Departments and 3 cross-cutting Research Domains, and it currently employs 230 people, including 90 scientists, 48 PhD students, 88 non-academic staff members and 4 apprentices. Working in close partnership with the scientific community, government agencies, as well as the private sector, IGB guarantees the development of innovative solutions to the most pressing challenges facing freshwater ecosystems and human societies. The unique long-term monitoring and research program at Lakes Mueggel and Stechlin, and the Spree and Tagliamento Rivers is pivotal for understanding and predicting global change impacts on freshwater ecosystems.